Introduction: Although psoriasis is a prevalent dermatological condition, its precise pathogenic mechanisms remain incompletely elucidated. Dysregulated autophagy has been increasingly recognized as contributing to the pathogenesis of certain skin disorders. LAMP2 is a key regulator within the autophagic machinery.
Objective: The objective of this work was to estimate serum level of LAMP2 in psoriatic individuals in a trial to elucidate its function in etiopathogenic pathways involved in the disease.
Patients and methods: This prospective case-control study encompassed 26 participants with different clinical types of psoriasis, and 26 healthy participants, matched for age and sex, were enrolled as the control group.Venous specimens drawn from peripheral sites (5 mL each) were obtained from all participants to determine serum LAMP2 levels using an ELISA assay.
Results: Serum LAMP2 levels were markedly elevated in patients (mean ± SD: 27.37 ± 33.25) compared to controls (3.03 ± 1.32) with high statistical significance (P<0.001).
Conclusion: LAMP2 could be incriminated in pathogenesis of psoriasis manifested by elevated serum levels of LAMP2 in psoriatic participants relative to the control group.
International Journal of Dermatology, Venereology and Leprosy Sciences
