2025, Vol. 8, Issue 2, Part B

Healthy hair is a sign of overall health and vitality. Premature graying of hair (PGH) have a unfavourable impact on an individual's self-esteem, as it is frequently perceived as a sign of aging. Hair graying known as achromotrichia or canities, is a natural by-product of aging. On the other hand, the age at which it manifests itself differs among various ethnicities. Uncertainties persist regarding the precise etiopathogenesis of graying. Autosomal dominant primary disease, PGH, is a scenario that may manifest. Progeria and pangeria are types of premature aging disorders that can also result in graying.

The control of cell proliferation and the inhibition of apoptosis have been associated with apoptosis protein family inhibitor and survivin. Survivin protein is a crucial a constituent of chromosomal passenger complex, which is necessary for cell division. Several autoimmune diseases were found to have survivin overexpression, which has important role in survival of auto-reactive T- and B-cell clones.