2025, Vol. 8, Issue 2, Part A

Introduction: DRESS syndrome is a severe drug-induced reaction with delayed onset and multiorgan involvement. Data from North Africa remain limited.

Objectives: To describe the clinical and biological features of DRESS in a Moroccan study.

Methods: We conducted a retrospective study of 77 patients diagnosed with DRESS according to RegiSCAR criteria.

Results: Patients had a mean age of 48 years; 64% were women. The average latency was 27 days. Rash was universal, with erythroderma in 66%. Fever, mucosal involvement, and lymphadenopathy were each present in over half of cases. Hypereosinophilia was noted in 79%. Hepatic involvement was most common. Allopurinol was the leading culprit drug (34%). Corticosteroids were used in 88%, with a favorable outcome in 83%. Five deaths occurred.