AbstractAcne vulgaris is a widespread dermatological condition with a multifactorial etiology. Emerging research highlights the potential role of micronutrients, particularly iron, in acne pathogenesis. This study investigates serum ferritin levels, a key biomarker of iron status, in individuals with acne compared to healthy controls.
Conducted as a hospital-based cross-sectional study over 18 months, the research included 70 acne patients and 70 age- and sex-matched controls. Participants' dietary habits, stress levels, physical activity, and acne severity were assessed, alongside serum ferritin and hemoglobin measurements.
The median ferritin level in the acne group was 19.0ng/mL, significantly lower than the control group, which had a median serum ferritin level of 30.4 ng/mL. Among acne patients, 55.7% exhibited ferritin deficiency (≤20 ng/mL), with 21.4% having very low levels (<10 ng/mL). In contrast, ferritin deficiency was less common in the control group. A significant difference in ferritin levels was observed between males and females, with males displaying higher ferritin levels in both groups. Additionally, lifestyle factors such as high-glycemic-index food consumption, stress, and physical inactivity were significantly associated with acne. Hemoglobin levels were slightly lower in the acne group compared to reference values and was statistically correlated with the GEA acne grade.
These findings highlight a potential link between serum ferritin levels and acne. Iron, as a critical micronutrient, influences skin health through its role in oxidative stress and immune response. The study also underscores the importance of considering dietary and lifestyle factors in acne management.
Further research is warranted to explore the complex interplay between iron metabolism, inflammation, and acne pathogenesis. Dietary interventions and iron supplementation could represent complementary strategies for managing acne, potentially improving patient outcomes.
