2024, Vol. 7, Issue 1, Part A

Author(s)
HHK Al-Shukri, Rawaa SA AL-Azawi, Suhad J Hadi, Sabreen Mohammed Abss, Baneen H Mohsen and Abbas A Sharhan

Abstract
Psoriasis is a chronic inflammatory skin disease that affects millions of people worldwide. While significant progress has been made in understanding the disease, the underlying genetic and biochemical mechanisms remain complex and multifaceted. This review aims to provide a comprehensive overview of the genetic and biochemical landscape of psoriasis, highlighting the key genes, pathways, and signaling molecules involved in the disease. We will discuss the genetic factors that contribute to the development of psoriasis, including the role of HLA-Cw6 and IL23R, as well as the biochemical pathways involved in the disease, including the IL-23/IL-17 axis and the role of cytokines and chemokines. This review also highlight the future directions in psoriasis research, including the potential for epigenetic and immunotherapeutic approaches to treatment. Overall, this review gave provide an understanding of the genetic and biochemical mechanisms underlying psoriasis, with the goal of informing the development of more effective treatments for this debilitating disease.

DOI: https://doi.org/10.33545/26649411.2024.v7.i1a.180

Pages: 43-46 | Views: 269 | Downloads: 100