AbstractBackground: Chronic urticaria (CU) is a complex dermatological disorder with an
unpredictable clinical course and multifactorial etiology. A systematic
clinicopathological evaluation can provide insight into underlying mechanisms
and aid in tailored treatment strategies.
Objective: To evaluate the clinical presentation and correlate histopathological
findings in patients with chronic urticaria attending a tertiary care hospital
in coastal Karnataka.
Methods: A cross-sectional study was conducted among 50 chronic urticaria
patients between May and August 2020. Clinical history, physical findings,
laboratory investigations, and skin biopsies were analyzed. Correlation between
clinical severity and pathological changes was statistically evaluated.
Results: Among 50 patients (32 females, 18 males), the most common symptoms
included erythematous wheals (100%) and pruritus (94%). Histopathology revealed
perivascular lymphocytic infiltrate in 84%, dermal edema in 66%, eosinophilic
infiltrate in 38%, and leukocytoclastic vasculitis in 8%. A significant
association (p<0.05) was observed between clinical severity and inflammatory
infiltrate density.
Conclusion: Chronic urticaria demonstrates variable histological patterns that
correlate with clinical severity. Routine skin biopsy in atypical cases may
support diagnostic precision and therapeutic decisions.
