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International Journal of Dermatology, Venereology and Leprosy Sciences

International Journal of Dermatology, Venereology and Leprosy Sciences

2019, Vol. 2, Issue 2, Part A

Assessment of efficacy of methotrexate and acitretin in the management of psoriasis
Author(s)
Roohi Sharma, Reeta Gupta and Pavan Malhotra
Abstract
Background: Psoriasis is a chronic inflammatory skin disease characterized by a prominent T-cell infiltrate, epidermal hyper proliferation and abnormal keratinocyte differentiation. The present study was conducted to assess efficacy of methotrexate and acitretin in the management of psoriasis.
Materials & Methods: 72 patients diagnosed with palmoplantar psoriasis were divided into 2 groups of 36 each. Group I patients were prescribed oral methotrexate15mg/week for 3 months and group II were given oral acitretin 0.5 mg/kg daily for 3 months. Modified psoriasis area severity index (MPASI) score was assessed.
Results: There were 16 males and 20 females in group I and 18 males and 18 females in group II. The mean MASI score at baseline, 1 month, 2 months and 3 months was 58.2, 38.4, 23.2 and 14.6 and 60.4, 40.2, 30.5 and 20.4 in group I and II respectively. The difference was significant (P< 0.05).
Conclusion: Oral methotrexate and acitretin were highly effective in treating palmoplantar psoriasis. Oral methotrexate reduces the lesions faster than acitretin.
Pages: 22-24 | Views: 125 | Downloads: 68
How to cite this article:
Roohi Sharma, Reeta Gupta, Pavan Malhotra. Assessment of efficacy of methotrexate and acitretin in the management of psoriasis. Int J Dermatol Venereology Leprosy Sci 2019;2(2):22-24. DOI: 10.33545/26649411.2019.v2.i2a.58
International Journal of Dermatology, Venereology and Leprosy Sciences