Vitamin B12 deficiency has been a known clinical entity for long. The present study was conducted to assess hyper-pigmentation in patients with vitamin B12 deficiency.
Materials & Methods: The present study was conducted on 32 patients of both genders visited to the department with complaint of hyper-pigmentation. History of diet, jaundice and skin changes was recorded. All patients were subjected to hematological evaluation.
Results: 14 were vegetarian and 18 were non- vegetarian, 32 had skin changes, 4 had jaundice. The difference was significant (P< 0.05). Mean hemoglobin was 6.12 gm/dl, WBC was 4.36 x 103/mm3, platelets was 1.28 x 106/mm3, RBC was 1.98 x 105/mm3, MCV was 107.2 fl, MCH was 32.4 pg, vitamin B12 was 124.2 pg/ml and folic acid was 7.8 ng/ml.
Conclusion: There was hyper-pigmentation of skin in which with vitamin B 12 deficiency. Thus patients should be carefully evaluated