AbstractIntroduction: Vitiligo is one of the most prevalent pigmentation disorders in the world characterized by the destruction of melanocytes and the development of white macules and patches on the skin or mucosa. The present study assessed thiol level in cases of Non-segmental vitiligo.
Materials & Methods: The present study was conducted on 185 cases (Group I) of vitiligo of both genders. Equal number of control (Group II) was also included. Venous blood samples of all participants were collected in tubes containing EDTA after fasting overnight. The total thiol content of the sample was measured using modified Ellman reagent. Values were presented as μmol/L
Results: Out of 185 patients, males were 87 and females were 98. The mean age of onset of vitiligo was 25.3 years, duration of disease was 21.5 years, VASI score was 0.74, staging score was 4 and spreading score was 1.2. The mean native thiiol in group I was 485.2 μmol/l and in group II was 450.1 μmol/l, disulphide level was 18.3 μmol/l in group I and 18.7 μmol/l in group II. Total thiol level was 503.5 μmol/l in group I and 468.8 μmol/l in group II. The difference was significant (P< 0.05).
Conclusion: Authors found that there was elevated thiol level in patients with vitiligo as compared to control.
